How is NUVIGIL different than modafinil?
NUVIGIL (R-modafinil) is the longer-lasting isomer of modafinil. Modafinil is 50% R-modafinil and 50% the shorter-lasting isomer S-modafinil.2 NUVIGIL stays in the blood longer than modafinil because it contains mostly R-modafinil.3 However, the amount of medicine in the blood does not necessarily reflect how well the medicine works. There are no clinical studies comparing the efficacy of NUVIGIL and modafinil.
