How is latent TB treated?
• Nine months of isoniazid (INH) is the preferred treatment regimen for all cases of latent TB, including HIV patients, pregnant women, and children. A minimum of 270 doses must be administered within 12 months. • In pregnancy, it is preferable to wait until the post-partum period to administer INH, unless the mother has HIV or a recent contact with active TB. Breastfeeding is not a contraindication to isoniazid. • Supplementation with 10-50 mg/day of Pyridoxine (vitamin B6), is recommended for use in the following instances: • During pregnancy, lactation, and the post-partum period. • In people with seizures. • In conditions with increased risk of peripheral neuropathy: diabetes, HIV, alcoholism, renal failure, and malnutrition ALTERNATIVE REGIMENS Isoniazid 900 mg twice weekly x 9 months (directly-observed therapy) Isoniazid 300 mg daily x 6 months Isoniazid 900 mg twice weekly x 6 months (directly-observed therapy) Rifampin 600 mg daily x 4 months • Six months of isoniazid is a more
