How is it that a test in the fingertip can ensure that I have checked the entire vascular system?
The endothelium is the same throughout all arteries in the body. The endothelium taken in aggregate, therefore, is the largest organ in the body. As a result, endothelial dysfunction is a systemic disorder. Endothelial dysfunction is involved in numerous systemic disease processes such as: erectile dysfunction, metabolic syndrome, cerebrovascular diseases (stroke/TIA), pre-eclampsia toxemia, renal failure, sleep apnea, claudication, and gangrene.In a study performed by Bonetti et al (*) at the Mayo Clinic, Rochester, a group of 94 subjects underwent angiographic assessment of coronary endothelial function and subsequent EndoPAT™ tests. Coronary endothelial function is quantified by injection of Ach during angiography. The EndoPAT™ which performs a non invasive test was found to be highly correlative to the angiography results. It was for this test that the EndoPAT™ got the FDA clearance for the detection of coronary endothelial dysfunction. An EndoPAT™ index cutoff value of 1.67 provid
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