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How is CIP (7-84 PTH) different from CAP (1-84 PTH)?

April 26, 2017cap CIP different Pth

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How is CIP (7-84 PTH) different from CAP (1-84 PTH)?

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As listed above, structurally, “CAP ” is 1-84 PTH and “CIP ” is most likely 7-84 PTH. Both CAP (1-84 PTH) and CIP (7-84 PTH) are secreted by the parathyroid gland. Functionally, CIP (7-84 PTH) causes the body to do the opposite of 1-84 PTH or CAP , in terms of serum calcium, osteoclast formation, bone resorption, bone turnover, and bone formation. CIP (7-84 PTH) has an inverse biological activity compared to that of 1-84 PTH. (ref. Slatopolsky et. al., Kidney International 2000; Vol.58:753-761. Divietti et. al., Endocrinology 2002; 143(1):171-176. Nguyen-Yamamoto et. al., Endocrinology 2001; 142(4);1386-1392. Faugere, et. al., “The Effects of PTH-(1-84) on Bone Turnover are Antagonized by PTH-(7-84) in Thyroparathyroidectomized and Nephrectomized Rats.” J Am Soc Nephrol 12:2001, 764A, presented at the ASN Annual Meeting, 2001.