How has the Archimedes Model been validated?
The core equations of the Model – those that describe the progression of diseases and how they respond to treatments – are validated by simulating actual clinical trials. This is a very deep validation that tests the entire chain of events from the fundamental biology and pathology of the disease, to the development of symptoms, patient behavior in seeking care, performance of tests, and delivery of treatments; to the changes in biological and health outcomes. The first 74 validations, involving eighteen clinical trials, were supervised by an independent committee of experts in diabetes and cardiovascular disease and have been published. The results of 71 of 74 comparisons between the real-world clinical trial and the Archimedes Model’s simulated trial were well within the sampling error. The other three either just missed or the description of the trial was incomplete. These validations involved 18 separate trials, 10 of which were not used to build the Model and provide independent v
