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How Far is San Diego from San Francisco?

April 26, 2017San Diego San Francisco

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How Far is San Diego from San Francisco?

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San Diego, California is located 502 miles south of San Francisco, California. Traveling by car down Interstate 5, it will take you about 7 hours 46 minutes to arrive. For a more scenic view, take CA-99 South. The mileage will be about 571 miles and you can expect to travel almost 10 hours.