HOW EFFECTIVE IS CELEBREX?
The effectiveness of CELEBREX was evaluated for the treatment of the signs and symptoms of Osteoarthritis of the knee and hip. To make this determination a placebo (sugar pill) was compared with CELEBREX treated patients in controlled clinical trials involving approximately 4,200 patients with Osteoarthritis. The clinical trials lasted up to 12 weeks in duration. In patients with Osteoarthritis, treatment with CELEBREX 100 mg BID or 200 mg one time each day resulted in an improvement in patient and physician assessments in Osteoarthritis severity taking into account joint pain, stiffness, and range of motion measures. In three 12-week studies of joint pain accompanying Osteoarthritis flare, CELEBREX doses of 100 mg given twice daily and 200 mg given twice daily provided significant reduction of pain within 24-48 hours of initiation of dosing. A total daily dose of 200 mg has been shown to be equally effective whether administered as 100 mg twice a day or 200 mg once a day.
