How does transdermal delivery decrease the incidence of adverse events?
Transdermal delivery enables drugs to be delivered systemically, bypassing the gastrointestinal tract and avoiding the first pass metabolism of the drug in the liver. Since first pass liver metabolism is avoided, lower doses of medication can be used, typically resulting in fewer side effects. Patches can also eliminate the personnel and equipment resources required for intravenous infusion, reducing the potential for disease transmission and site infection associated with these delivery methods.
