HOW DOES TIAMULIN AFFECT BACTERIAL PATHOGENS?
Tiamulin, macrolides, chloramphenicol, and lincosamides have very similar antibacterial effects; however, their ways of producing these effects slightly but significantly differ. All of them inhibit bacterial protein synthesis by interfering with the 50S bacterial ribosomal subunits after the protein synthesis has begun. How far from the start of the protein synthesis before any of these antibiotics exert its action makes the difference. Studies done at the molecular level showed tiamulin interferes with bacterial protein synthesis earlier and faster than other similar antibiotics. This allows for the manufacture of the most incomplete bacterial proteins, which results in a greater bacteriostatic effect. Bacteriostatic effect means the bacterial growth and population are only reduced but bacteria remain viable. It is the natural immune defense mechanisms of the patient animals that eventually would kill the bacteria. In contrast, antibiotics, such as amoxicillin, gentamicin, and the fl
