How does the topical peptide work in the epidermis or dermis level?
Peptides penetrate skin via intercellular routes, transcellular pathways, and appendageal routes (hair follicles/sweat glands). Most formulations use penetration enhancers or carriers (like liposomes) to improve absorption, as peptides are typically too large to pass through the stratum corneum easily.
Receptor binding occurs through random molecular movement and chemical affinity – peptides don’t actively “seek” receptors. When a peptide encounters its matching receptor, they bind based on complementary molecular structures.
No waiting period is necessary between different peptides. Receptors are highly specific and only bind to their intended peptide ligands regardless of application timing. The concept of “receptor confusion” isn’t supported by biochemical evidence.
In general cosmetic chemistry practice, the rule of thumb for layering peptide products is 30-60 seconds between applications. This isn’t because of receptor binding issues, but rather to:
1. Allow each product to settle into the skin
2. Prevent pilling (products balling up on the skin)
3. Ensure proper pH equilibration
The exception is if you’re using peptides in combination with:
– Direct acids (wait 10-15 minutes)
– Vitamin C (wait 10-15 minutes)
– Retinoids (use at different times of day)
But between different peptide products alone, 30-60 seconds is sufficient.
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