How does the sensitivity of serum Freelite tests compare with capillary zone electrophoresis (CZE)?
CZE of serum is more sensitive than SPE but less sensitive than IFE for detecting monoclonal proteins. In a recent study, it was shown that sFLC assays detected all monoclonal FLCs from patients with LCMM that were missed by CZE but detected by IFE. If CZE is used for initial detection of monoclonal proteins, sFLC assays will detect additional patients.
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