How does the project form a vector cross-product of existing research themes by the participants?
Existing research directions. Bricker’s group has been involved in the structural characterization of membrane protein complexes for fifteen years Limbach’s group has focused on developing new analytical mass spectrometric approaches for the analysis of complex biomolecule systems. Bricker and Limbach have recently begun a collaborative project aimed at developing new mass spectrometric approaches for the analysis of hydrophobic peptides. During that collaborative project, these investigators have found that analysis bottlenecks include the lengthy sample preparation steps and the poor sensitivity of conventional sample preparation techniques. Soper’s group has focused on fabricating micro-instrumentation using PMMA instead of traditional glass-based substrates. His group has also used these devices for high-throughput analysis of DNA for sequencing and diagnostic applications. New research direction. This project will bring together for the first time this diverse group of investigato
