How does the Mechanism of Action search field work in Investigator Portal?
The Mechanism of Action field utilizes a controlled vocabulary that describes the various types of mechanisms of action for bioactive compounds — for example, Angiotensin-l Converting Enzyme (ACE) Inhibitors, Calcium Channel Blockers, Angiotensin Receptor Antagonists, Dopamine D1 Agonists, etc. The Mechanism of Action search field is useful for retrieving very specific groups of compounds that work by the same mechanism. It can also be used with the Boolean operator AND to search for compounds with a dual mechanism of action — such a search example would “Angiotensin-I Converting Enzyme (ACE) Inhibitors” AND “Neprilysin (Enkephalinase, Neutral Endopeptidase, NEP) Inhibitors”. The Browse Index for the Mechanism of Action search field provides a highly targeted approach to selecting search terminology for use in accordance with a hierarchical scheme. This search field can also be used to select terms from an alphabetic list or users can use the pre-search field (Lookup box) to create a s
