How does the manner in which a chemical is used contribute to the overall risk?
How a chemical is used can contribute greatly to (or subtract from) the overall risk. The basic premise is the same: how difficult is it to contain the material? If the procedure calls for large quantities of a chemical to be used in a large, open reaction vessel instead of a micro-scale, closed system, then there is greater potential for exposure to the chemical. If the experimental procedure is so physically large and unwieldy such that it cannot be placed inside a chemical fume hood, and thus more difficult to contain, then exposure becomes more likely. If the reaction vessel is heated and creates pressures that are greater than one (> 1) atmosphere, or if the vessel is brought to a near-vacuum, the more likely the reaction vessel will break and release its contents. Carefully consider the chemical- and physical properties of the chemicals you will use, as well as other aspects of your experimental procedure that could contribute to the hazard. The risks associated with a high hazar
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