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How does Sulfamethoxazole and Trimethoprim / Generic Bactrim work?

April 26, 2017bactrim generic sulfamethoxazole trimethoprim

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How does Sulfamethoxazole and Trimethoprim / Generic Bactrim work?

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Sulfamethoxazole inhibits the conversion of para amino benzoic acid (PABA) to dihydrofolate (DHFA) by inhibiting folate synthetase enzyme. Trimethoprim inhibits bacterial dihydrofolate reductase and blocks the conversion of dihydrofolate (DHFA) to tetra hydro folate (THFA). Thus Bactrim causes a sequential block of folate metabolism in bacteria.