How does SUBOXONE* work?
SUBOXONE binds to mu-opioid receptors in the brain, and it has a stronger chemical attraction and bond than most full agonists (eg, methadone, heroin, oxycodone, hydrocodone, and morphine). When a person begins SUBOXONE therapy, he/she should be in a mild-to-moderate state of withdrawal from the misused opioid. Then, as the other opioid leaves the person’s system, buprenorphine attaches to the opioid receptors, withdrawal symptoms are relieved, and the patient begins to feel better. At adequate maintenance doses, buprenorphine occupies most receptors and, in a dose-dependent manner, blocks other opioids from attaching. Buprenorphine has a long duration of action; it does not wear off quickly, allowing for once-daily dosing. Buprenorphine has also been shown to reduce cravings, reduce illicit drug use, and improve treatment retention.
