How does R-Lipoic Acid differ from Alpha Lipoic Acid?
Molecules in living systems generally exist in only one form. When the same molecules are synthesized in the laboratory they consist of equal amounts of both forms. Examples of this would include: dl alpha tocopherol (synthetic Vitamin E) and d alpha tocopherol (natural Vitamin E). The synthetic ‘unnatural’ form of ALA is Alpha RS-Lipoic Acid or more commonly called alpha lipoic acid and the natural “fully active’ form is alpha R-Lipoic acid. The ‘R’ form is the proper structural fit for membrane receptors and enzymes and therefore is metabolized more efficiently and with much greater potency. Taking more synthetic ALA has not been shown to give the same benefit as R-Lipoic Acid. It is best to avoid Alpha RS-Lipoic Acid! Apparently the S-Lipoic Acid form actually interferes with the proper metabolism of the bioactive R-form. In one animal study with mice ALA at high doses shortened their mean lifespan, but even low doses of the R- form increased their total lifespan. Alpha R-Lipoic aci
