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How does Protandim send a message to our cells to activate Nrf2? Can these pathways be blocked by heavy metals?

April 26, 2017activate blocked cells heavy message metals nrf2 Pathways protandim send

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How does Protandim send a message to our cells to activate Nrf2? Can these pathways be blocked by heavy metals?

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Protandim activates several kinase pathways that result in the phosphorylation of Nrf2, allowing its translocation to the nucleus where it binds to and regulates genes with an ARE sequence in their promoter. These pathways are not blocked by heavy metals.