How does Primidone work?
Primidone helps control the electrical activity in the brain that is responsible for seizures. The main metabolic products of the drug are phenobarbital and phenylethylmalonamide (PEMA), both of which are known to have anticonvulsant effects. Primidone works by blocking the sodium channels of cell membranes. This action helps prevent neurons, or nerve cells, from the repetitive firing action that contributes to seizures. Primidone may be prescribed by veterinarians for the long-term management of seizures caused by primary epilepsy, which is caused by inherited or genetic factors, and secondary epilepsy, which is associated with an underlying illness, infection, poisoning, injury, nutritional condition, or other disorder. The drug may be prescribed for the treatment of generalized (tonic clonic/grand mal) seizures, marked by signs like rapid movement of limbs, chewing, pupil dilation, salivation and loss bowel or bladder control. Primidone may also be to manage petite mal or absence se
