How does myasthenia gravis affect the muscular system?
myasthenia gravis is an autoimmune disorder wherein the immune system of the body attacks the acetyl choline receptors of the post synaptic neuromuscular junction. Decreased numbers of functioning nicotinic acetylcholine receptors therefore impairs muscular contraction by limiting depolarization. Muscle fibers of patients with MG are easily fatigued, and thus do not respond as well as muscles in healthy individuals to repeated stimulation.Medication consists mainly of cholinesterase inhibitors to directly improve muscle function and immunosuppressant drugs to reduce the autoimmune process.
