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How does Metformin-Rosiglitazone / Generic Avandamet work?

April 26, 2017avandamet generic metformin-rosiglitazone

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How does Metformin-Rosiglitazone / Generic Avandamet work?

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Metformin suppresses hepatic gluconeogenesis and glucose output from liver. Metformin enhance insulin mediated glucose disposal in muscle and fat. Metformin enhance GLUT1 transport from intracellular site to plasma membrane. Pioglitazone is a selective agonist of peroxisome proliferator-activated factor ? (PPAR?). PPAR receptors are found in adipose tissue, skeletal muscle and liver. Pioglitazone reverse insulin resistance by stimulating GLUT4 expression and translocation.