How does LYRICA differ from NSAIDs and COX-2 inhibitors?
A6: LYRICA does not affect the arachadonic acid pathways, the pathways affected by NSAIDs and COX-2 inhibitors. While there is strong evidence to suggest that NSAIDs, via inhibition of prostanoids, are effective in nociceptive pain, their efficacy in the treatment of neuropathic pain has not been established. NSAIDs and COX-2 inhibitors are not indicated for the treatment of neuropathic pain.