How does Levothyroxine Sodium / Generic Synthroid work?
Thyroid hormone synthesis and secretion is regulated by the hypothalamic-pituitary-thyroid axis. Thyrotropin-releasing hormone (TRH) released from the hypothalamus stimulates secretion of thyrotropin-stimulating hormone, TSH, from the anterior pituitary. TSH is responsible for synthesis of thyroxine and tri iodo thyronine. The thyroxine and tri iodo thyronine binds with nuclear receptors. Tri iodo thyronine receptor complex binds to thyroid hormone response element and results in gene transcription. This results in expression of predetermined genetically coded pattern of protein synthesis.
