How does LCIS develop?
A. woman’s breast contains numerous milk-producing lobules and milk-carrying ducts, which connect the lobules to the nipple. LCIS starts in the breast lobules. A normal lobule is lined with small, rectangular cells with a small, discrete central nucleus. An early step in the development of LCIS is hyperplasia, in which these normal cells increase in number and pile up upon themselves in the lobules. When the lobules become filled with abnormal cells that have changed in cellular structure (i.e. enlarged, irregularly-shaped cells with large, diffuse nuclei), the condition is labeled LCIS. In the final step, the abnormal cells break through the lining of the lobules and invade into the breast tissue. This process is called invasion, and has the potential to spread beyond the breast.
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