How Does It Work For Plantar Fibromatosis?
As with many medications, the exact way Transdermal Verapamil 15% Gel helps plantar fibromatosis is not entirely understood. It is proposed that two different processes are taking place. The first allows for the progression of the condition to be slowed or stopped and second for the fibroma to actually be reduced, which allows for the symptoms of the condition to be reduced or eliminated. Both of these processes are effected by verapamil’s ability as a calcium channel blocker to block calcium. Cells known as fibroblasts are responsible for the production of the primary components of plantar fibromas such as collagen, fibronectin and glycosaminoglycans. Research has shown that the process by which these components are released out of the fibroblast requires calcium. It has been found that calcium channel blockers have the ability to decrease the production of collagen and fibronectin and their release from the fibroblast*. A study has also shown that the large increase of fibroblasts in
As with many medications, the exact way Transdermal Verapamil 15% Gel helps plantar fibromatosis is not entirely understood. It is proposed that two different processes are taking place. The first allows for the progression of the condition to be slowed or stopped and second for the fibroma to actually be reduced, which allows for the symptoms of the condition to be reduced or eliminated. Both of these processes are effected by verapamil’s ability as a calcium channel blocker to block calcium. Cells known as fibroblasts are responsible for the production of the primary components of plantar fibromas such as collagen, fibronectin and glycosaminoglycans. Research has shown that the process by which these components are released out of the fibroblast requires calcium. [1] It has been found that calcium channel blockers have the ability to decrease the production of collagen and fibronectin and their release from the fibroblast. [2] A study has also shown that the large increase of fibrobl
