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How does IHC testing work?

April 26, 2017ihc Testing

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How does IHC testing work?

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• A: In HER2-positive tumors, there is an excess amount of the HER2 protein on the cell surface. This is referred to as HER2 overexpression. IHC assays measure the amount of HER2 protein expressed on the surface of tumor cells.This technique uses antibodies to HER2 and a chemical detection method to stain HER2 protein in the breast tissue samples. IHC tests are scored on a scale of 0 to 3+ based on the reviewer’s interpretation of staining intensityand completeness of cell membrane staining.17 The test is usually performed on formalin-fixed, paraffin-embedded tissues.

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Posted

• A: In HER2-positive tumors, there is an excess amount of the HER2 protein on the cell surface. This is referred to as HER2 overexpression. IHC assays measure the amount of HER2 protein expressed on the surface of tumor cells. This technique uses antibodies to HER2 and a chemical detection method to stain HER2 protein in the breast tissue samples. IHC tests are scored on a scale of 0 to 3+ based on the reviewer’s interpretation of staining intensity and completeness of cell membrane staining.9 The test is usually performed on formalin-fixed, paraffin-embedded tissues.