How does “Creatinine” test help with adulteration and quantitation?
Creatinine is a normal compound excreted at a constant rate by the kidney into the urine. Creatinine concentration is measured to determine the relative water content of the urine sample. Since the concentration of drugs (e.g. THC metabolite) and creatinine increase or decrease in parallel, dividing the drug concentration/creatinine concentration eliminates water as an unknown. Analysis of this data over time is valuable in assessing continued drug abstinence.