How does CHAVI plan to investigate the correlates of immune protection in the SIV/macaque model?
In our original application this study was not expanded to the degree that we ultimately planned that it would be because of limitations in the original grant. So in the second year of the grant, Norm Letvin with multiple collaborators is now putting together an expanded program that will focus on two areas; one is to determine the correlates of protection in live attenuated SIV infection and the other is to study host-virus interactions in dual infections, and to study these in tandem. When live attenuated infection is protective, what are the immune correlates of that protection? And when superinfection occurs, what has the first infection done to the immune system to allow the second infection? That program is just being worked out, and so we’ll have more details in a couple of months. So you’re pretty pleased with progress so far? I’m thrilled with progress so far, because everyone has accepted this philosophy and has dealt marvelously with the controlled chaos that has come out of
