How does Celebrex work?
NSAIDs target an enzyme called cyclooxegenase that is responsible for much inflammation behind pain. But it turned out there are two types of this enzyme. Cox-2 was behind the inflammation, while cox-1 actually protects the stomach lining. Unfortunately, NSAIDs target both which often can result in ulcers.The mechanism of action of Celebrex is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and at therapeutic concentrations in humans, Celebrex does not inhibit the cyclooxygenase-1 (COX-1) isoenzyme.The theory was that if scientists could develop a more specific drug that targeted just cox-2, it would alleviate pain and inflammation while not effecting the delicate lining of the stomach.In studies of about 13,000 patients, it appeared to work almost as well as prescription-strength naproxen in-patients with osteoarthritis. In rheumatoid arthritis sufferers, it appeared to work almost as well as another popular NSAID, dic
NSAIDs target an enzyme called cyclooxegenase that is responsible for much inflammation behind pain. But it turned out there are two types of this enzyme. Cox-2 was behind the inflammation, while cox-1 actually protects the stomach lining. Unfortunately, NSAIDs target both which often can result in ulcers. The mechanism of action of Celebrex is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and at therapeutic concentrations in humans, Celebrex does not inhibit the cyclooxygenase-1 (COX-1) isoenzyme. The theory was that if scientists could develop a more specific drug that targeted just cox-2, it would alleviate pain and inflammation while not effecting the delicate lining of the stomach. In studies of about 13,000 patients, it appeared to work almost as well as prescription-strength naproxen in-patients with osteoarthritis. In rheumatoid arthritis sufferers, it appeared to work almost as well as another popular NSAID,
