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How does a low pathogenic avian influenza virus (LPAI) becomes a high pathogenic Avian Influenza virus (HPAI)?

April 26, 2017avian high HPAI Influenza low lpai pathogenic virus

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How does a low pathogenic avian influenza virus (LPAI) becomes a high pathogenic Avian Influenza virus (HPAI)?

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After transfer of AIVs to a new type of host, either birds or mammals, influenza viruses sometimes undergo genetic mixing and develop into new high pathogenic strains that pose serious threats to their new hosts, be they poultry, wild bird species, or even humans.