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How do you get rid of a recurring Pyogenic Granuloma that has caused Osteomylitis and amputation of a big toe?

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How do you get rid of a recurring Pyogenic Granuloma that has caused Osteomylitis and amputation of a big toe?

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Skin grafts have been attempted as has numerous excisions. Osteomylitis of the bones in the great toe resulted in amputation of the toe. Wound flap failed and wound has taken 4 months to heal, now is beginning to over granulate again. No history of diabetes or any other such.

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