How do you deal with a patient who has a hypersensitivity reaction to carboplatin?
Maurie Markman, MD: This is a little contentious and I think there are certain people that would disagree with what I’m going to tell you now. I think that carboplatin is a wonderful drug in the second line setting. But, I have great respect in a negative way for the hypersensitivity reactions when they occur. The fact is that this is palliative therapy, not curative therapy in the second line setting. So, if I have a patient who has a significant hypersensitivity reaction — by that I mean, drop in blood pressure, wheezing, shortness of breath, diffuse erythroderma — I would not re-treat that patient with carboplatin. There are those that would say they would try a de-sensitization protocol, give steroids, give very low doses like we have done routinely with Taxol. I personally would not do that. If on the other hand, I had a patient that only had a mild rash, or perhaps a little cough, or maybe a little itching, and they have had a good response to carboplatin; I think it would be r
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