How do viruses impact neutrophils?
From The Merck Manual : “Transient neutropenia often accompanies viral infections (eg, early-stage infectious mononucleosis), and sepsis is a particularly serious cause of neutropenia. Neutropenia associated with common childhood viral diseases occurs during the first 1 to 2 days of illness and may persist for 3 to 8 days. It usually corresponds to a period of acute viremia and is related to virus-induced redistribution of neutrophils from the circulating to the marginal pool. Neutrophil sequestration may occur after viral tissue damage. Moderate to severe neutropenia may also be associated with a wide variety of other infections (see Table 135-2). Chronic neutropenia often accompanies HIV infection, the result of impaired production of neutrophils and accelerated destruction of neutrophils by antibodies (see Ch. 145). Autoimmune neutropenias may be associated with the presence of circulating antineutrop
(see a Doctor) Neutrophils eat viruses and other cells infected by viruses. Numbers of neutrophils can go down after or during a viral infection because many of the neutrophils leave the blood to fight the infection in the tissues and so normal blood values are reduced. There’s millions of online general reference sites but see a Doctor. And on preview…..there’s one reference.
Thanks for the Merck reference, Ervin. My Google-fu had failed me. I’m already under a doctor’s care. I am just looking for more information on a comment she made about viruses causing your neutrophil count to drop. I’ve had two blood tests showing very low neutrophil counts (700 followed by 439) despite all other counts being normal. We’ve ruled out a number of conditions. AFAIK, I do not have cancer and am not undergoing immunosuppressive chemotherapy. We’re actually trying to figure out why I am constantly fighting sinus infections, bronchitis or the like. Tests, like last week’s CAT scan, show the infections are real. Unfortunately, a week off antibiotics and I’ve got another infection. In three weeks, she hopes I’ll be healthy enough to get a base line neutrophil count to see if I have naturally occuring neutropenia. In the meantime, it looks like I’ll become acquainted with an immunologist.
