How do tricyclic antidepressants treat fibromyalgia symptoms?
The tricyclic antidepressants, including Elavil and Pamelor, work by raising the levels of neurotransmitters in the brain. When the tricyclic antidepressants are prescribed in low doses, they often help improve the quality of sleep. Tricyclic antidepressants increase levels of serotonin and norepinephrine in the brain. Patients with chronic pain often have decreased levels of these calming neurotransmitters. Tricyclics can relax painful muscles and heighten the effects of endorphins — the body’s natural painkillers. On the other hand, tricyclic antidepressants may cause drowsiness, dizziness, dry mouth, dry eyes, and constipation.
