How do the plaques revealed by the Campbell-Switzer stain in transgenic mouse models compare with staining using antibodies against different forms of amyloid?
A. Some antibodies show only a subset of plaques revealed by the Campbell-Switzer method, while others appear to be a one to one match. The Campbell-Switzer stain is unique in its ability to differentiate its staining of immature (diffuse) and mature (congophilic) plaques, allowing researchers a unique observational capability.
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