How do the levels of protein production compare in goats and traditional bioreactors?
There are two ways of addressing the question of comparing expression rates in traditional bioreactors or goats. In the straightforward way, the way you asked the question, is that a typical production rate in a bioreactor is 600 milligrams per liter of product. In a goat, a typical range will be on the order of let’s say 2 to 8 grams per liter. But the second point to make here is you’re really talking about a completely different apples-and-oranges comparison. That expression rate is extremely critical in a bioreactor because you have a fixed wall and it’s a batch process. In goats it’s less critical, to be honest, because regardless of what the expression rate is, you simply breed more animals to get to the number you need to produce the quantity you want, and you’re producing it continuously vs. depending upon a batch and the inherent risks of losing that batch. So there are really two answers here. Number one, transgenics is somewhat better in expression rate typically, and number
