How do people become leptin resistant?
This is the subject of much research. It appears that people become leptin resistant by the same general mechanism that causes people to become insulin resistant – by repeated overexposure to high levels of the hormone. High blood glucose levels cause repeated surges in insulin and in turn this causes one’s cells to become insulin resistant. This resistance is what leads to diabetes. It is much the same as being in a smelly room for a period of time. Soon, you stop being able to smell it because the signal no longer gets through.
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