How do NSAIDs work and how do they cause stomach problems?
A. Prostaglandins are natural chemicals which are involved in body inflammation. By inhibiting the body’s production of certain chemical messengers (prostaglandins), NSAIDs decrease inflammation. However, certain prostaglandins are also important in protecting the stomach lining from the corrosive effects of stomach acid as well as playing a role in maintaining the natural healthy condition of the stomach lining. These prostaglandins are produced by an enzyme called Cox-1. By blocking the Cox-1 enzyme and disrupting the production of prostaglandins in the stomach, NSAIDs can cause ulcers and bleeding. Some NSAIDs have less effect on the stomach prostaglandins than others, and, therefore a lower risk of ulcer formation.
