How do Muvs and Vuls arise?
Muvs are indicative of “overinduction” of the Pn.p cells, while Vuls exhibit “underinduction.” One can imagine the degree of induction can be affected by several mechanisms/events: positive effects through the amount of signal produced in the AC (Muv = more signal, Vul = less signal) and through reception and transduction of the signal in the Pn.p cells (Muv = gf receptor, signal transduction machinery, or target genes, Vul = lf of these) and negative effects by repressors of induction in the AC or Pn.p cells (Muv = lf of repressor, Vul = gf of repressor). The phenotypes of different genes and their locus of function will tell you which steps they mediate.
