How do LTL cancer tissue lines compare with subcutaneous tumor grafts?
LTL cancer tissue lines are established by implanting donor cancer tissues into the subrenal capsule graft site instead of the conventionally used subcutaneous graft site. The subrenal capsule graft site appears to be superior as indicated by very high engraftment rates of donor tissues (>95%) compared to the much lower take rates reported for subcutaneous grafts (20-40%). Consequently, the subrenal capsule graft site allows superior retention of the cancers’ subpopulations and hence characteristics of the donor cancers. In view of this, the LTL cancer tissue lines provide better cancer models than subcutaneous tumor grafts.
