How do I invert a chiral center?
In the Add Fragment [+] mode, inversion of a chiral center is achieved by holding down the CTRL + Option key and Double Clicking (left mouse button) on the chiral atom. It is useful to have R/S chirality selected as a Label to confirm you have inverted as you wanted. In some heterocyclic rings it may be impossible to invert chirality in this manner. If this is the it may be necessary to physically ‘break’ a bond, invert chirality, then re -‘make’ the bond in order to invert a chiral center.
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