How do I estimate the budget for structure determination centers?
A. The RFA gives some very broad guidelines. 1) No more than half the total direct cost budget should be planned for consortium arrangements with the PSI:Biology structure centers. 2) A rough estimate is $10,000 per soluble protein target. This estimate is actually based on the cost per solved protein structure for the current PSI. Many more targets were attempted than are actually solved. Therefore the figure of $10,000 might more likely be applied per family of closely related proteins. For more difficult proteins, the cost is obviously higher, but difficult to know. Estimate the amount of work based on the level of effort that is expected.
A. The FOA gives some very broad guidelines. 1) No more than half the total direct cost budget should be planned for consortium arrangements with the PSI:Biology structure centers. 2) A rough estimate is $10,000 per soluble protein target. This estimate is actually based on the cost per solved protein structure for the current PSI. Many more targets were attempted than are actually solved. Therefore the figure of $10,000 might more likely be applied per family of closely related proteins. For more difficult proteins, the cost is obviously higher, but difficult to know. Estimate the amount of work based on the level of effort that is expected.
