How do heavy metals cause Cardiovascular Disorders and Central Nervous System problems?
Let’s take CNS problems and neuropathology first. There are a number of mechanistic bases for metal neurotoxicity such as: * Disturbances of macromolecular synthesis and metabolism, such as those of protein and nucleic acids * Disturbance of Ca2+ homeostasis * Oxidative injury * Aberrant protein phosphorylation * Some metals such as lead will affect the integrity of the blood-brain-barrier (bbb) leading in changes to astrocyte functioning.
