How Do Angiotensin Receptor Blockers Work?
Angiotensin receptor blockers work by inhibiting the effects of a hormone called angiotensin 2, which produces a number of effects in the body: Constriction of blood vessels, increased salt and water retention, activation of the sympathetic nervous system, stimulation of blood vessel and heart fibrosis (stiffening), and promotion of heart cell growth. Together, these effects can increase blood pressure and in some situations be harmful to the heart and kidneys. For angiotensin 2 to produce its effects in the body, it must bind to a receptor in much the same way that a key must fit into a lock to open a door. Angiotensin receptor blockers prevent angiotensin 2 from binding to its receptor and thus reduce the effects of angiotensin 2. Most of the angiotensin receptor blockers, except for Benicar (Sankyo Pharma, Inc), are also available in combination with an additional medication called hydrochlorothiazide (HCTZ), a diuretic that is very effective in lowering blood pressure. The blood pr
