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How did the Bubonic Plague end in Europe 16th century?

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How did the Bubonic Plague end in Europe 16th century?

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I seem to recall that it just “ran it’s course”. But the only thing definitive that I could find was this: “The plague of London in 1665 killed over 17,000 people (almost twenty percent of the city’s population). This outbreak was quelled by a huge fire that destroyed most of the city.” That seems to be the only “reason” for the plague ending, at least in London…

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