How can two people without aniridia produce a child with aniridia?
Both parents of an aniridic can be “normal,” having NO genetic mutation or deletion of the PAX 6 gene. If these two people have an aniridic child, the aniridia is called “sporadic,” The child obtained this genetic mutation or deletion from a spontaneous change in the egg or sperm. The condition existed BEFORE conception. So, there was NOTHING done during the pregnancy that caused this problem. If these two parents should have another child, the chance of aniridia occurring in the next pregnancy is the same chance as any one else in the general population – very slim.
