How can Tox21 enhance regulatory testing?
Using more human-relevant methods, as the NRC Vision recommends, will allow regulatory agencies like the EPA to better understand the direct effects of a chemical on humans at a molecular level. Because many tests can be run at once, scientists can investigate the effects of mixtures of chemicals, and a larger range of low and high doses, on human cells and tissues. The NRC Vision recommends a nationally-integrated biomonitoring program, which will detect potential chemicals exposures before they become harmful. Eventually, these methods will also allow a much more thorough examination of the potential effects of chemicals on sensitive populations, such as developing children, workers, or those with genetic susceptibilities. Finally, we will be able to save a great deal of time and money and assess many more chemicals than currently possible with animal tests.
