How can Tox21 approaches be incorporated into TSCA reform?
Basic strategies that save animals must be written into revised TSCA legislation. These include the release of existing data on industrial chemicals, whether from industry files or other testing programs like HPV or REACH, and the formation of categories of chemicals to allow read-across of hazard data among similar chemicals. Chemicals should be prioritized based on human or environmental exposures, and priority should be given to chemicals of known concern, such as those that bioaccumulate or persist in the environment. A minimum list of toxicity tests to be conducted on all chemicals is not appropriate—and simply not feasible. Instead, integrated testing strategies, which rely on all existing information in a weight-of-evidence approach, should be created for chemicals or groups of chemicals. In vitro and in silico (computer-based) techniques can be used now to test many chemicals at once. This would reduce the uncertainty that currently exists and give regulatory agencies much more
