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How can the test for spina bifida and other open neural tube defects be made more sensitive?

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How can the test for spina bifida and other open neural tube defects be made more sensitive?

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Combining the Afp4 test with a detailed second trimester ultrasound between 19 and 22 menstrual weeks when a detailed evaluation of the brain and spine can be performed is approximately 95% sensitive in detecting open neural tube defects.

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