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How can so many different organs be affected by tuberous sclerosis?

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How can so many different organs be affected by tuberous sclerosis?

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Both the TSC1 and TSC2 genes are believed to suppress tumour growth in the body. When either of these genes are defective, tumours are not suppressed and tuberous sclerosis results. The genes also play a role in the early fetal development of the brain and skin.

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